Molecular Formula | C19H18Cl2N3NaO5S |
Molar Mass | 494.32 |
In vitro study | Dicloxacillin Sodium is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. It is effective against β-lactamase-producing microorganisms such as Staphylococcus aureus, which are resistant to most other penicillins. Like other beta-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits the cross-linking of linear peptidoglycan multimeric chains that make up the main components of the cell wall of gram-positive bacteria. Dicloxacillin is not sensitive to β-lactamases (also known as penicillinase) secreted by many penicillin-resistant bacteria. The presence of an isoxazole group on the side chain of a Penicillin core is advantageous against β-lactamase because β-lactamase is relatively intolerant of steric hindrance in the side chain. Thus, it is capable of binding to penicillin binding proteins (PBPs) and inhibiting peptidoglycan cross-linking, but not by beta-lactamase binding or inactivation. |